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M9550087.TXT
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1995-03-04
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Document 0087
DOCN M9550087
TI Mother-to-infant transmission of hepatitis C virus. Lombardy Study Group
on Vertical HCV Transmission.
DT 9505
AU Zanetti AR; Tanzi E; Paccagnini S; Principi N; Pizzocolo G; Caccamo ML;
D'Amico E; Cambie G; Vecchi L; Institute of Virology, University of
Milan, Italy.
SO Lancet. 1995 Feb 4;345(8945):289-91. Unique Identifier : AIDSLINE
MED/95139683
AB To assess the risk of mother-to-infant transmission of hepatitis C virus
(HCV), we followed up 116 babies of anti-HCV positive mothers, of whom
22 were coinfected with HIV and 94 had HCV alone. None of the babies
whose mothers had HCV alone acquired HCV, while 8 babies (36%; p <
0.001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV
and HIV (3). There was no association between any specific maternal HCV
genotype and enhanced risk of neonatal infection. HCV-RNA levels were
significantly higher (p < 0.05) in mothers with HIV coinfection than in
those with HCV alone. These data indicate that maternal HIV status
correlates with enhanced level of viraemia which favours neonatal
infection.
DE Adolescence Adult Breast Feeding *Disease Transmission, Vertical
Female Follow-Up Studies Hepatitis Antibodies/BLOOD Hepatitis
C/BLOOD/COMPLICATIONS/*TRANSMISSION Hepatitis C Viruses/IMMUNOLOGY
Human HIV Infections/*COMPLICATIONS/TRANSMISSION Infant, Newborn
Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).